Epiphanius in his youth spent several years as a monk in Egypt, and his fame in the Nile valley grew great according to his legendary Vita. That he still had much influence among Egyptian monks after leaving them behind, is seen from the introduction to his Ancoratus, written against heretics and in particular Origenists in 374. The treatise was written on the request of among others a certain Hypatios from Egypt, possibly a monk, who would have reported on the problems they experienced with Origenistic-leaning monks living among them. The present paper will consider the translation of the Ancoratus into Coptic, and the role this translation might have played in the Origenistic controversy in late fourth- and early fifth-century Egypt.